CCND1 ELISA Kit for Human(Homo sapiens) | EIAab.comCCND1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CCND1(Gene name) > Human

CCND1 (Gene name),

G1/S-specific cyclin-D1 (Protein name ), CCND1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CCND1(BCL1;PRAD1);

Protein name:

G1/S-specific cyclin-D1;

Alternative:

BCL-1 oncogene;B-cell lymphoma 1 protein(BCL-1);PRAD1 oncogene;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2.

Function:

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subcellular Location:

Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

Protein Attributes:

Sequence length:

295

Sequence:

50:

100:

150:

200:

250:

295:

IEALLESSLR | QAQQNMDPKA | AEEEEEEEEE | VDLACTPTDV | RDVDI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P24385

STRING:

9606.ENSP00000227507

UniGene:

Hs.523852

SMR:

P24385

Pfam:

PF02984

KEGG:

hsa:595

MIM:

168461

Uniprot:

P24385

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ELISA Kit for Human G1/S-specific cyclin-D1

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E0585h

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ELISA Kit for Human G1/S-specific cyclin-D1

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E0585m

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96T

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ELISA Kit for Human G1/S-specific cyclin-D1

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E0585r

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ELISA Kit for Human G1/S-specific cyclin-D1

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E0585b

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ELISA Kit for Human G1/S-specific cyclin-D1

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E0585d

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96T

ELISA Kit for Human G1/S-specific cyclin-D1

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E0585c

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96T

CLIA Kit for Human G1/S-specific cyclin-D1

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U0585b

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96T

CLIA Kit for Human G1/S-specific cyclin-D1

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U0585c

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96T

CLIA Kit for Human G1/S-specific cyclin-D1

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U0585h

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96T

CLIA Kit for Human G1/S-specific cyclin-D1

Cat.:

U0585m

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96T

CLIA Kit for Human G1/S-specific cyclin-D1

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U0585d

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96T

CLIA Kit for Human G1/S-specific cyclin-D1

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U0585r

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96T

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Polyclonal Antibody for Human G1/S-specific cyclin-D1

Cat.:

P0585Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human G1/S-specific cyclin-D1

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P0585Rb-h

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Polyclonal Antibody for Human G1/S-specific cyclin-D1

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P0585Rb-r

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Polyclonal Antibody for Human G1/S-specific cyclin-D1

Monoclonal Antibody for Human G1/S-specific cyclin-D1

Protein for Human G1/S-specific cyclin-D1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"CLM3, a multitarget tyrosine kinase inhibitor with antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo"

A Antonelli, G Bocci, P Fallahi, et al.

From:The Journal of Clinical Endocrinology & Metabolism

References

1.

"A novel cyclin encoded by a bcl1-linked candidate oncogene."
Motokura T. , Bloom T. , Kim H.G. , Jueppner H. , Ruderman J.V. , Kronenberg H.M. , Arnold A.
Nature350:512-515(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast."
Lew D.J. , Dulic V. , Reed S.I.
Cell66:1197-1206(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Human D-type cyclin."
Xiong Y. , Connolly T. , Futcher B. , Beach D.
Cell65:691-699(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Characterization of a candidate bcl-1 gene."
Withers D.A. , Harvey R.C. , Faust J.B. , Melnyk O. , Carey K. , Meeker T.C.
Mol. Cell. Biol.11:4846-4853(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias."
Rimokh R. , Berger F. , Bastard C. , Klein B. , French M. , Archimbaud E. , Rouault J.-P. , Santa Lucia B. , Duret L. , Vuillaume M.
Blood83:3689-3696(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

NIEHS SNPs program
Submitted (2002-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Placenta.
9.

"The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint."
Motokura T. , Arnold A.
Genes Chromosomes Cancer7:89-95(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66
tissue: Placenta.
10.

"CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1."
Bates S. , Bonetta L. , McAllan D. , Parry D. , Holder A. , Dickson C. , Peters G.
Oncogene9:71-79(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK4 AND CDK6
11.

"Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines."
Chesi M. , Bergsagel P.L. , Brents L.A. , Smith C.M. , Gerhard D.S. , Kuehl W.M.
Blood88:674-681(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MULTIPLE MYELOMA
12.

"New functional activities for the p21 family of CDK inhibitors."
LaBaer J. , Garrett M.D. , Stevenson L.F. , Slingerland J.M. , Sandhu C. , Chou H.S. , Fattaey A. , Harlow E.
Genes Dev.11:847-862(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK4 IN THE CCND1-CDK4-CDKN COMPLEX;SUBCELLULAR LOCATION;FUNCTION
13.

"Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286."
Germain D. , Russell A. , Thompson A. , Hendley J.
J. Biol. Chem.275:12074-12079(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;MUTAGENESIS OF THR-286 AND THR-288
14.

"Cyclin-dependent kinases regulate the antiproliferative function of Smads."
Matsuura I. , Denissova N.G. , Wang G. , He D. , Long J. , Liu F.
Nature430:226-231(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF CCND1-CDK4 COMPLEX IN SMAD PHOSPHORYLATION
15.

"INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."
Liu W.D. , Wang H.W. , Muguira M. , Breslin M.B. , Lan M.S.
Biochem. J.397:169-177(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH INSM1
16.

"Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."
Wang H.W. , Muguira M. , Liu W.D. , Zhang T. , Chen C. , Aucoin R. , Breslin M.B. , Lan M.S.
J. Endocrinol.198:29-39(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH INSM1
17.

"Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."
Zhang T. , Liu W.D. , Saunee N.A. , Breslin M.B. , Lan M.S.
J. Biol. Chem.284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INSM1 AND CDK4
18.

"Suppression of cancer cell growth by promoting cyclin D1 degradation."
Shan J. , Zhao W. , Gu W.
Mol. Cell36:469-476(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP2;UBIQUITINATION;DEUBIQUITINATION BY USP2
19.

"F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage."
Santra M.K. , Wajapeyee N. , Green M.R.
Nature459:722-725(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-286;UBIQUITINATION;MUTAGENESIS OF THR-286
20.

"NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor."
Mori T. , Ikeda D.D. , Fukushima T. , Takenoshita S. , Kochi H.
Cell Cycle10:3284-3299(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH UHRF2
21.

"Crystal structure of human CDK4 in complex with a D-type cyclin."
Day P.J. , Cleasby A. , Tickle I.J. , O'Reilly M. , Coyle J.E. , Holding F.P. , McMenamin R.L. , Yon J. , Chopra R. , Lengauer C. , Jhoti H.
Proc. Natl. Acad. Sci. U.S.A.106:4166-4170(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-271 IN COMPLEX WITH WILD TYPE AND MUTANTS ALA-172; PHE-172 AND ASP-172 CDK4

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